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June 1, 1975Circulation Research

"Prorenin" in human plasma?

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Population

Normal subjects and patients with essential hypertension

Design

Other

Follow-up

12 months (storage duration)

Authors

JSJ E SealeyCornell UniversityJLJ. H. LaraghGeneral Cardiology

Discussion

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Implication

Storage may artifactually activate prorenin; leaves open its role in low-renin hypertension.

Structured PICO

P
Population
Normal subjects and patients with essential hypertension (including 4 patients with low-renin essential hypertension)
I
Intervention
Prolonged storage of plasma at -20 degrees C; sodium deprivation and administration
O
Outcome
Plasma renin activity and 'prorenin' levelssurrogate

The study identifies an inactive form of renin ('prorenin') in human plasma that is activated by cold storage and responds abnormally to sodium depletion in some patients with low-renin essential hypertension.

Cite This Study

Sealey et al. (1975) studied this question.

synapsesocial.com/papers/6a856aefee60e6e86dae5dafhttps://doi.org/10.1161/01.res.36.6.10

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Response of plasma prorenin and active renin to chronic and acute alterations of renin secretion in normal humans. Studies using a direct immunoradiometric assay.1989 · 86 citations
  2. 2Effect of temperature on plasma renin samples.1978 · 19 citations
  3. 3Human Prorenin: Pathophysiology and Clinical Implications1988 · 44 citations
  4. 4Different Secretion Patterns of Active and Inactive Renin in Man1978 · 30 citations
  5. 5Evidence for the presence of differently glycosylated forms of prorenin in the plasma of anephric man.1992 · 13 citations