Key result
Plasma renin activity remained stable for three days at 4°C, but decreased by up to 74% at 24°C and increased by 22% after freezing and thawing.
Why the study?
How does storage temperature affect plasma renin activity in samples from hypertensive patients?
Population
Peripheral venous plasma samples from 22 hypertensive patients
Comparison
Storage of Na2EDTA-contained plasma samples at… vs Parallel samples immediately cooled in an…
Design
Other
Follow-up
up to 3 days
Authors
Loading...
May warrant 4°C plasma storage for renin assays; leaves open standardized preanalytical protocols in hypertension research.
How does storage temperature affect plasma renin activity in samples from hypertensive patients?
Blood for renin analysis must be cooled to 4°C within 2-3 hours to maintain stability, as freezing or room temperature storage alters renin activity.
Fyhrquist et al. (1978) studied Hypertension (n=22). Storage temperature (-20, 4, and 24 degrees C, and lyophilized) vs. Immediate cooling to 4 degrees C was evaluated on Plasma renin activity. Plasma renin activity remained stable for three days at 4°C, but decreased by up to 74% at 24°C and increased by 22% after freezing and thawing.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: