What question did this study set out to answer?

To examine the natural course of cardiomyopathy and evaluate progressive changes in left ventricular function across different age groups in patients with Duchenne muscular dystrophy.

January 1, 1979Japanese Circulation Journal-english EditionOpen Access

アンジオテンシンi変換酵素阻害剤sq14225の腎血管性高血圧症における作用 : 第43回日本循環器学会学術集会 : 高血圧ii

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Why the study?

What is the natural course of cardiomyopathy and left ventricular dysfunction in patients with Duchenne muscular dystrophy?

Population

Patients with Duchenne muscular dystrophy

Design

Cohort

Follow-up

average 5.4 years (range 1 to 9 years)

Authors

HTHIROMITSU TANAKA SNS. NishiThe University of Osaka HKHIROSHI KATANASAKO

Discussion

Member takes

Implication

Progressive DMD cardiomyopathy may warrant serial monitoring; leaves open intervention timing in observational data.

Key Points

To examine the natural course of cardiomyopathy and evaluate progressive changes in left ventricular function across different age groups in patients with Duchenne muscular dystrophy.
Followed 40 patients with serial electrocardiograms (ECGs) over 1 to 9 years (mean 5.4 years) to identify regional lesions using leads V1, I, V5, and aVF.
Evaluated left ventricular function via echocardiography and mechanocardiography in 33 patients stratified into three age groups (6–10, 11–15, and ≥16 years) compared to age-matched normal controls.
Cardiac involvement progressed in location or severity in 75% of patients over time, typically originating in the posterobasal portion and spreading to the lateral wall of the left ventricle.
Left ventricular function deteriorated progressively with age: stroke index was significantly decreased at 6–10 years; almost all echocardiographic parameters decreased and the PEP/ET ratio increased at 11–15 years; and all parameters showed worsening at ≥16 years.

Structured PICO

What is the natural course of cardiomyopathy and left ventricular dysfunction in patients with Duchenne muscular dystrophy?

Population

Patients with Duchenne muscular dystrophy (n=40 for long-term ECG observation, n=33 for left ventricular function assessment divided into three age groups: 6-10 years, 11-15 years, and ≥16 years)

Comparator

Age-matched normals

Outcome

Natural course of cardiomyopathy assessed by electrocardiogram (ECG) abnormalities and left ventricular function (echocardiography and mechanocardiography)surrogate

Patients with Duchenne muscular dystrophy develop progressive cardiomyopathy, typically commencing with posterobasal ECG changes and advancing to progressive left ventricular systolic dysfunction as they age.

Cite This Study

TANAKA et al. (1979) studied this question.

synapsesocial.com/papers/6a7055c835aa2c282ce1a47a https://doi.org/10.1253/jcj.43.974

Topics

Cardiomyopathy Echocardiography

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アンジオテンシンi変換酵素阻害剤sq14225の腎血管性高血圧症における作用 : 第43回日本循環器学会学術集会 : 高血圧ii

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

アンジオテンシンi変換酵素阻害剤sq14225の腎血管性高血圧症における作用 : 第43回日本循環器学会学術集会 : 高血圧ii

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider