Why the study?
Does hyperosmotic mannitol reduce early membrane damage during coronary reperfusion in a canine model of myocardial ischemia?
Population
30 adult mongrel dogs weighing 20-25 kg subjected to 1-hour circumflex coronary artery occlusion.
Comparison
Radiolabeled anticardiac myosin2 antibody… vs Nonspecific2 fragments; or reflow without…
Design
Preclinical
Follow-up
Up to 6 hours of reflow
Authors
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Hyperosmotic mannitol attenuates early membrane damage in canine reperfusion; leaves open translation to human outcomes.
Does hyperosmotic mannitol reduce early membrane damage during coronary reperfusion in a canine model of myocardial ischemia?
Membrane damage develops early during coronary reperfusion following ischemia, and part of this damage can be prevented by altering reflow conditions with hyperosmotic mannitol.
Frame et al. (1983) studied this question.
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