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December 1, 1978CirculationOpen Access

Early imaging of experimental myocardial infarction by intracoronary administraion of 131I-labelled anticardiac myosin (Fab')2 fragments.

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Why the study?

Does intracoronary injection of 131I-labelled cardiac myosin-specific antibody (Fab')2 allow early imaging of experimental myocardial infarction in dogs?

Population

16 dogs with experimental myocardial infarction induced by 5-hour occlusion of the left anterior descending…

Comparison

Intracoronary injection of 500 muCi of… vs Non-infarcted dogs, and simultaneous injection…

Design

Preclinical

Follow-up

one-half hour after injection

Authors

BKB A KhawDuke-NUS Medical SchoolHGHerman K. GoldInterventional CardiologyRLRobert C. LeinbachCardiac Imaging

Discussion

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Implication

Supports targeted early infarct imaging in canine models; leaves open clinical translation for human myocardial infarction detection.

Structured PICO

Does intracoronary injection of 131I-labelled cardiac myosin-specific antibody (Fab')2 allow early imaging of experimental myocardial infarction in dogs?

P
Population
16 dogs with experimental myocardial infarction induced by 5-hour occlusion of the left anterior descending coronary artery
I
Intervention
Intracoronary injection of 500 muCi of 131I-labelled cardiac myosin-specific antibody (Fab')2
C
Comparator
Non-infarcted dogs, and simultaneous injection of 125I-labelled nonimmune IgG (Fab')2
O
Outcome
Uptake of 131I in the infarcted region on in vivo scintograms one-half hour after injectionsurrogate

Intracoronary administration of myosin-specific antibody fragments enables specific and early (one-half hour) imaging of myocardial infarcts in an experimental model.

Cite This Study

Khaw et al. (1978) studied this question.

synapsesocial.com/papers/6a832e5688eff2bd7befed06https://doi.org/10.1161/01.cir.58.6.1137
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Localization of cardiac myosin-specific antibody in myocardial infarction.1976 · 144 citations
  2. 2Technetium-99m stannous pyrophosphate myocardial scintigraphy. Reliability and limitations in assessment of acute myocardial infarction.1977 · 51 citations
  3. 3Technetium stannous pyrophosphate myocardial scintigrams in patients with chest pain of varying etiology.1975 · 209 citations
  4. 4Cardioversion and "false positive" technetium-99m stannous pyrophosphate myocardial scintigrams.1976 · 78 citations
  5. 5Adenosinetriphosphatase Activity of Cardiac Myosin1966 · 69 citations