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March 1, 1988European Heart Journal

Monoclonal antibodies specific for human cardiac myosin: selection, characterization and experimental myocardial infarct imaging

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Population

10 dogs with experimental myocardial infarction

Design

Preclinical

Follow-up

5 h

Authors

EHEike HobergJagiellonian UniversityMEMichael EisenhutLuton and Dunstable University Hospital NHS Foundation TrustMHMichael HofmannTriemli Hospital

Discussion

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Implication

Fab fragments enable experimental infarct imaging; leaves open background reduction for clinical translation.

Structured PICO

P
Population
10 dogs with experimental myocardial infarction
I
Intervention
Iodine-123 labelled anti-myosin antibodies (undigested antibody molecules or their Fab fragments) injected intravenously
O
Outcome
Accumulation of radioactivity in myocardial infarction assessed by in vivo imaging and in vitro scintigraphysurrogate

Iodine-123 labelled Fab fragments of anti-myosin antibodies allow for in vivo imaging of experimental myocardial infarction, though background accumulation remains a limitation.

Limitations

  • Clear differentiation between infarcted and noninfarcted myocardium was limited by accumulation of radioactivity in the thoracotomy wound, in the liver, and in the stomach.

Cite This Study

Hoberg et al. (1988) studied this question.

synapsesocial.com/papers/6a7c49d5d501feb4353be78fhttps://doi.org/10.1093/oxfordjournals.eurheartj.a062504
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Localization of cardiac myosin-specific antibody in myocardial infarction.1976 · 144 citations
  2. 2Early imaging of experimental myocardial infarction by intracoronary administraion of 131I-labelled anticardiac myosin (Fab')2 fragments.1978 · 63 citations
  3. 3Applications of anticardiac myosin monoclonal antibodies in the diagnosis of heart disease.1985 · 2 citations
  4. 4Monoclonal Antibody to Cardiac Myosin: Imaging of Experimental Myocardial Infarction1984 · 152 citations
  5. 5111In monoclonal antimyosin antibody imaging: Imaging of myocardial infarction and myocarditis.1990 · 7 citations