In order to elucidate the rate of uptake of exogenous fatty acids in small and large adipose tissue fat cells different experiments were performed in vitro and in vivo. Lipoprotein lipase eluted with heparin in vitro or assayed directly on extracts of the tissue was determined in rat or human adipose tissue with varying fat cell size. Furthermore, lipoprotein lipase activity was determined in fat cells from the same tissue separated into size classes by a flotation technique. All experimental approaches indicated higher activity in large fat cells in comparison with small fat cells.
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Björntorp et al. (1975) studied this question.