Specific Na+,K+-ATPase isozymes are localized to distinct subcellular domains in ventricular myocytes, with α2β1 implicated in regulating sarcoplasmic reticulum calcium content.
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Implicates α2β1 in SR Ca²⁺ regulation; hypothesis-generating for isozyme-targeted therapies pending human validation.
Harada et al. (2006) studied this question.
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