What question did this study set out to answer?

This review aims to explore how microgravity-induced changes in gut bacteria affect brain health and cognitive function.

Microgravity-Induced Gut Dysbiosis and its Consequences for Brain Health

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Review identifies gut dysbiosis from microgravity impacts brain health, suggesting intervention strategies for astronauts.

This review aims to explore how microgravity-induced changes in gut bacteria affect brain health and cognitive function.
Synthesis of evidence from human spaceflight missions, ground-based analogue studies, and preclinical models.
Evaluation of compositional changes in gut microbiota and their impact on the gut-brain axis.
Critical assessment of mechanistic pathways and research limitations.
Microgravity exposure leads to a shift in the Firmicutes-to-Bacteroidetes ratio and depletion of beneficial bacteria.
Reduced production of short-chain fatty acids due to gut dysbiosis correlates with neuroinflammation and compromised gut integrity.
Evidence points to systemic inflammation and brain dysfunction resulting from these gastrointestinal changes.

Sappa et al. (2026) studied this question.

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