March 1, 1963Development

Regional Organization of Pre-pacemaker Cells in the Cardiac Primordia of the Early Chick Embryo

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Population

Early chick embryo lateral cardiac primordia (anterior, middle, and posterior fragments)

Comparison

Incubation at 37°C in culture medium for 48 hours vs Comparison between anterior, middle, and…

Design

Preclinical

Follow-up

48 hours

Authors

RDRobert L. DeHaanUniversity of British Columbia

Discussion

Member takes

Implication

Pacemaker gradient originates in early embryo; extends developmental models but leaves open human relevance.

Structured PICO

Population

Early chick embryo lateral cardiac primordia (anterior, middle, and posterior fragments)

Intervention

Incubation at 37°C in culture medium for 48 hours

Comparator

Comparison between anterior, middle, and posterior fragments

Outcome

Presence of spontaneously beating heart tissue and intrinsic pulsation ratesurrogate

The antero-posterior rate gradient observed in the functional heart is already defined in specific, localized portions of the heart-forming regions in the early embryo.

Cite This Study

Robert L. DeHaan (1963) studied this question.

synapsesocial.com/papers/6a705c418031ec7bb1dc4816 https://doi.org/10.1242/dev.11.1.65

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Regional Organization of Pre-pacemaker Cells in the Cardiac Primordia of the Early Chick Embryo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regional Organization of Pre-pacemaker Cells in the Cardiac Primordia of the Early Chick Embryo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider