Why the study?
Is depression associated with altered hemodynamic, hemostatic, and endothelial responses to acute psychological stress in postcoronary angiography patients?
Is depression associated with altered hemodynamic, hemostatic, and endothelial responses to acute psychological stress in postcoronary angiography patients?
Depression in postcoronary angiography patients is associated with altered stress reactivity, providing a potential mechanistic link to increased CAD risk.
Depression-linked blunted cardiac and heightened platelet stress reactivity may elevate CAD risk in post-angiography patients; hypothesis-generating and requires prospective confirmation.
Although there is evidence that depression is associated with an increased risk for coronary artery disease (CAD), the mechanisms underlying this association remain unclear. This study examined the association between depression and hemodynamic, hemostatic, and endothelial responses to psychological stress. Seventy-two postcoronary angiography patients completed a mental stress task. Blood pressure, heart rate, and impedance cardiography were recorded at rest and during the task. Blood samples were taken at the end of rest and immediately after the task. Depression was evaluated using the Diagnostic Interview Schedule Self-Administered (DISSA). In total, 21% of the participants were depressed. Analyses revealed that depression was associated with blunted pre-ejection period stress reactivity and with increased platelet factor 4 reactivity. These data provide potential mechanistic pathways linking depression to increased CAD.
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Plourde et al. (2013) studied this question.
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