Why the study?
Acute aortic dissection often leads to out-of-hospital cardiac arrest and death before hospital arrival, prompting investigation into differences in incidence by sex.
Does female sex affect prehospital mortality in patients with acute aortic dissection?
Population
266 patients with incident acute aortic dissection in a city with 121,180 residents
Comparison
Women vs men with acute aortic dissection
Design
Population-based observational study
Key result
Women with acute aortic dissection had significantly higher prehospital mortality than men (37% vs 21%; OR 2.24; 95% CI 1.30-3.87; P=0.004).
Authors
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Alerts clinicians to higher prehospital mortality risk in women with aortic dissection; leaves open confirmation and causes in prospective studies.
Observational (n=266)
Does female sex affect prehospital mortality in patients with acute aortic dissection?
Odds Ratio: 2.24 (95% CI 1.3–3.87)
Absolute Event Rate: 37% vs 21%
p-value: p=0.004
Women with acute aortic dissection are older, more likely to have type A dissection, and experience significantly higher prehospital mortality compared to men.
Marume et al. (2023) conducted an observational in Acute aortic dissection (n=266). Female sex vs. Male sex was evaluated on Prehospital mortality (OR 2.24, 95% CI 1.30-3.87, p=0.004). Women with acute aortic dissection had significantly higher prehospital mortality than men (37% vs 21%; OR 2.24; 95% CI 1.30-3.87; P=0.004).