Why the study?
Does intracoronary ergonovine induce a biphasic response in coronary arterial diameter?
Does intracoronary ergonovine induce a biphasic response in coronary arterial diameter?
Intracoronary ergonovine can induce a biphasic response in coronary arterial diameter, with dilation at lower doses and constriction at higher doses.
Single-case biphasic ergonovine response warrants caution in provocation testing; leaves open reproducibility and clinical relevance.
This report presents a case of paradoxical coronary arterial dilation induced by intracoronary ergonovine. When compared with the control angiogram, the right coronary artery obviously dilated with selective, intracoronary administration of cumulative doses of 5 micrograms and 15 micrograms ergonovine without concomitant hemodynamic changes. Additional intracoronary infusion of 35 micrograms ergonovine into the right coronary artery inversely increased vascular tone of the vessel associated with a focal hyperconstriction. Such a biphasic response of arterial diameter to intracoronary ergonovine was also observed in the left coronary artery, but the degree of dilation was much smaller.
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Mohri et al. (1988) studied this question.
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