Key result
Oral administration of 1 g acetylsalicylate significantly blunted peak reactive hyperemia in forearm muscle compared to placebo (27.2 vs. 32.4 ml/min/100 ml tissue, p=0.003).
Why the study?
Does acetylsalicylic acid or laterality affect reactive hyperemia in forearm skin and muscle in healthy volunteers?
Population
23 lean, healthy, non-smoking male volunteers aged 18-30 years.
Comparison
Oral acetylsalicylic acid 1 g or dominant… vs Placebo or non-dominant forearm measurement.
Design
Other, Randomized order for acetylsalicylate vs placebo ingestion…
Follow-up
Acute (measurements taken within 2 hours after ingestion)
Authors
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NSAID intake blunts muscle reactive hyperemia; supports avoiding aspirin before endothelial testing in research but leaves clinical impact open.
RCT (n=23)
Randomized crossover
No
Does acetylsalicylic acid or laterality affect reactive hyperemia in forearm skin and muscle in healthy volunteers?
Absolute Event Rate: 27.2% vs 32.4%
p-value: p=0.003
When using reactive hyperemia as a surrogate endpoint for endothelial function, laterality does not confound results, but NSAID intake can blunt the response in muscle and reduce its duration in skin.
Addor et al. (2008) conducted an RCT in Healthy volunteers (n=23). Acetylsalicylic acid vs. Placebo was evaluated on Peak reactive hyperemia in forearm muscle (ml/min/100 ml tissue) (p=0.003). Oral administration of 1 g acetylsalicylate significantly blunted peak reactive hyperemia in forearm muscle compared to placebo (27.2 vs. 32.4 ml/min/100 ml tissue, p=0.003).
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