Key result
Frovatriptan and almotriptan generally reduced systolic, diastolic, and mean arterial blood pressure in both male and female rats, while significantly increasing heart rate only in male rats.
Why the study?
To assess the impact of second-generation triptans frovatriptan and almotriptan on hemodynamic parameters in male and female rats.
Does single administration of frovatriptan or almotriptan alter hemodynamic parameters in intact male and female rats?
Does single administration of frovatriptan or almotriptan alter hemodynamic parameters in intact male and female rats?
Frovatriptan and almotriptan exert hypotensive effects in intact rats, with sex-specific differences such as tachycardia occurring only in males, highlighting complex serotonergic cardiovascular modulation.
Answers are grounded in this paper and cite their sources.
Suggests possible sex-specific triptan effects on hemodynamics; leaves open translation to human patients.
The introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses not only the typical 5-HT1B/1D receptor agonist activity, but shows an affinity to the 5-HT1F receptor. The aim of our study was to assess the impact of frovatriptan and almotriptan on hemodynamics in male and female rats. We used a non-invasive "tail-cuff" method to measure the arterial blood pressure. Female and male Wistar rats were treated separately with high and low dosages of frovatriptan and almotriptan. Male and female rats showed reduction in all hemodynamic parameters, but only male rats showed an increase in the heart rate. In general, we could say that both almotriptan and frovatriptan potentiate cardiovascular safety.
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Saracheva et al. (2020) studied Healthy (intact rats) (n=80). Frovatriptan and Almotriptan vs. Saline 0.9% NaCl was evaluated on Hemodynamic parameters (systolic, diastolic, mean arterial pressure, pulse pressure, and heart rate) (p=<0.05). Frovatriptan and almotriptan generally reduced systolic, diastolic, and mean arterial blood pressure in both male and female rats, while significantly increasing heart rate only in male rats.
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