What question did this study set out to answer?

To determine whether prolonged left ventricular unloading with isosorbide-5-mononitrate combined with late reperfusion produces superior functional recovery and limits remodeling compared with late reperfusion alone.

August 15, 1995Circulation

Impact of Left Ventricular Unloading After Late Reperfusion of Canine Anterior Myocardial Infarction on Remodeling and Function Using Isosorbide-5-Mononitrate

View Full Paper

Ask AI

Bookmark

Why the study?

Does prolonged unloading with isosorbide-5-mononitrate improve ventricular function and attenuate remodeling in dogs with late reperfusion of acute anterior myocardial infarction?

Population

Dogs with anterior myocardial infarction induced by left anterior descending coronary artery ligation…

Comparison

Isosorbide-5-mononitrate 25 mg IV over 4 hours… vs Placebo

Design

Preclinical, randomized

Follow-up

6 weeks

Authors

BJBodh I. JugduttUniversity of Alberta MKMohammad I. KhanShifa Tameer-e-Millat University SJS. Joanne JugduttUniversity of Alberta

Discussion

Member takes

Implication

May inform nitrate unloading strategies post-MI; leaves open translation from this canine model to human late reperfusion.

Key Points

To determine whether prolonged left ventricular unloading with isosorbide-5-mononitrate combined with late reperfusion produces superior functional recovery and limits remodeling compared with late reperfusion alone.
Canines were randomized to reperfusion 2 hours after left anterior descending coronary artery ligation followed by either isosorbide-5-mononitrate (n = 12; 25 mg IV over 4 hours, then 50 mg PO QID for 6 weeks) or placebo (n = 12).
Left ventricular function and topography were evaluated in vivo with echocardiography at baseline, 2 days, and 6 weeks, alongside postmortem planimetry and collagen hydroxyproline quantification.
By 2 days, the isosorbide-5-mononitrate group achieved an 18% greater ejection fraction (P < .025) and 26% less asynergy (P < .05) relative to placebo.
At 6 weeks, isosorbide-5-mononitrate resulted in significantly greater ejection fraction (P < .001) and less asynergy (P < .001) compared with placebo.
Treated animals had significantly smaller infarct and noninfarct segment lengths, ventricular volumes, mass, scar size, and scar collagen content (all P <= .05).

Structured PICO

Does prolonged unloading with isosorbide-5-mononitrate improve ventricular function and attenuate remodeling in dogs with late reperfusion of acute anterior myocardial infarction?

Population

Dogs with anterior myocardial infarction induced by left anterior descending coronary artery ligation followed by reperfusion 2 hours later (n=28 total; 24 randomized to main study, 4 in acute study)

Intervention

Isosorbide-5-mononitrate (ISMN) 25 mg IV over 4 hours followed by 50 mg PO QID for 6 weeks

Comparator

Placebo

Outcome

Left ventricular function and topography (echocardiograms), postmortem topography (planimetry), and collagen (hydroxyproline) at 6 weekssurrogate

Prolonged unloading with isosorbide-5-mononitrate combined with late reperfusion improves ventricular function and reduces remodeling in a canine model of anterior myocardial infarction.

Cite This Study

Jugdutt et al. (1995) studied this question.

synapsesocial.com/papers/6a7063be660549caf2c4f752 https://doi.org/10.1161/01.cir.92.4.926

Topics

Echocardiography

View Full Paper

Ask AI

Bookmark

Impact of Left Ventricular Unloading After Late Reperfusion of Canine Anterior Myocardial Infarction on Remodeling and Function Using Isosorbide-5-Mononitrate

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Impact of Left Ventricular Unloading After Late Reperfusion of Canine Anterior Myocardial Infarction on Remodeling and Function Using Isosorbide-5-Mononitrate

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider