January 1, 1981CirculationOpen Access

Effect of intravenous nitroglycerin on collateral blood flow and infarct size in the conscious dog.

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Why the study?

Does intravenous nitroglycerin reduce infarct size and improve collateral blood flow in a canine model of acute coronary occlusion?

Population

43 previously instrumented conscious dogs with permanent occlusion of the mid-circumflex coronary artery

Comparison

6-hour intravenous infusions of nitroglycerin to… vs 6-hour intravenous infusions of saline (n=18)

Design

Preclinical

Follow-up

2 days

Authors

BJBodh I. JugduttUniversity of Alberta LBLewis C. BeckerCardiac Imaging GHGrover M. HutchinsUniversity of Southern California

Discussion

Member takes

Implication

Hypothesis-generating for nitroglycerin in acute occlusion; prospective human trials needed before clinical adoption.

Structured PICO

Does intravenous nitroglycerin reduce infarct size and improve collateral blood flow in a canine model of acute coronary occlusion?

Population

43 previously instrumented conscious dogs with permanent occlusion of the mid-circumflex coronary artery

Intervention

6-hour intravenous infusions of nitroglycerin (NG) to reduce mean arterial pressure by 10% but not below 90 mm Hg (n=15), or NG followed by methoxamine (MX) to correct the NG-induced fall in blood pressure (n=10), begun within 3 minutes of occlusion

Comparator

6-hour intravenous infusions of saline (n=18)

Outcome

Infarct size (as a percent of left ventricle and as a percent of occluded bed) and coronary blood flowsurrogate

Intravenous nitroglycerin reduces infarct size and improves collateral blood flow in a canine model of acute coronary occlusion, likely via direct vasodilation rather than reduced myocardial oxygen demand.

Cite This Study

Jugdutt et al. (1981) studied this question.

synapsesocial.com/papers/6a73f6ff2960bd03ae1ee830 https://doi.org/10.1161/01.cir.63.1.17

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Effect of intravenous nitroglycerin on collateral blood flow and infarct size in the conscious dog.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of intravenous nitroglycerin on collateral blood flow and infarct size in the conscious dog.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider