Why the study?
Does intravenous nitroglycerin reduce infarct size in conscious dogs with coronary occlusion?
Population
92 conscious dogs with coronary occlusion (65 survived for 24 hours)
Comparison
Nitroglycerin 200-300 microgram/min i.v. for 8… vs Untreated dogs (n=32)
Design
Preclinical
Follow-up
24 hours
Authors
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IV nitroglycerin does not reduce infarct size in this canine model; leaves open translation to human acute MI.
Does intravenous nitroglycerin reduce infarct size in conscious dogs with coronary occlusion?
Prolonged intravenous nitroglycerin increased subendocardial coronary blood flow but did not decrease infarct size in a canine model of sustained coronary occlusion.
Fukuyama et al. (1980) studied this question.
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