Why the study?
Does briefly ischemic and reperfused myocardium display an exaggerated response to subsequent coronary flow reductions, and is this mediated by oxygen free radicals?
Does briefly ischemic and reperfused myocardium display an exaggerated response to subsequent coronary flow reductions, and is this mediated by oxygen free radicals?
Briefly ischemic and reperfused myocardium exhibits an exaggerated contractile decline to subsequent flow reductions, representing a subtle manifestation of myocardial stunning mediated by oxygen free radicals.
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Implicates oxygen free radicals in postischemic stunning in animals; hypothesis-generating and leaves open human translation.
Schröder et al. (1988) studied this question.
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