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February 13, 2020The Journal of Physiology8 citationsOpen Access

Heat treatment improves the exaggerated exercise pressor reflex in rats with femoral artery occlusion via a reduction in the activity of the P2X receptor pathway

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Population

Rats with peripheral artery disease (PAD) induced by femoral artery occlusion

Comparison

Heat treatment vs Control rats and/or PAD rats without heat…

Design

Preclinical

Follow-up

3 days

Key result

Heat treatment attenuated the exaggerated blood pressure response to muscle contraction in rats with peripheral artery disease by reducing P2X receptor pathway activity.

Authors

LQLu QinQLQin LiJLJianhua Li

Discussion

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Overview

Heat treatment warrants clinical investigation in PAD; leaves open translation of P2X effects to humans.

Structured PICO

P
Population
Rats with peripheral artery disease (PAD).
I
Intervention
Heat treatment (increase in basal muscle temperature of ~1.5°C for 30 min, twice daily for three continuous days)
C
Comparator
Control rats and/or PAD rats without heat treatment
O
Outcome
Blood pressure (BP) response to static muscle contraction and α,β-methylene ATPsurrogate

Heat treatment improves the exaggerated exercise pressor reflex in a rat model of peripheral artery disease by reducing P2X receptor pathway activity.

Cite This Study

Qin et al. (2020) studied Peripheral artery disease (PAD). Heat treatment vs. Control rats was evaluated on Blood pressure response to static muscle contraction. Heat treatment attenuated the exaggerated blood pressure response to muscle contraction in rats with peripheral artery disease by reducing P2X receptor pathway activity.

synapsesocial.com/papers/6a7063be6c240de38cdbc8afhttps://doi.org/10.1113/jp279230
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