Key result
Food availability during the light-time in combination with phase delay shifts decreased the amplitude and spectral power of circadian oscillations of blood pressure, heart rate, and locomotor activity more than phase delay shifts alone.
Why the study?
Do phase delay shifts of light combined with food restriction or increased salt intake alter circadian oscillations of blood pressure and heart rate in rats?
Do phase delay shifts of light combined with food restriction or increased salt intake alter circadian oscillations of blood pressure and heart rate in rats?
Combining phase delay shifts with food restriction during the passive phase significantly disrupts circadian rhythms of blood pressure and heart rate in rats, which may have implications for shift workers.
Mistimed feeding may worsen phase-shift effects on cardiovascular rhythms in animals; leaves open human translation and clinical relevance.
Effects of phase delay shifts (PDS) of light in combination with moderately increased salt intake (SL) (2%) or time restriction of food (FR) during the light-time (passive phase) on heart rate (HR), blood pressure (BP) and locomotor activity (LA) in radiotelemetry-measured rats were evaluated. PDS decreased amplitude and spectral power of circadian oscillations of HR, BP and LA. Moderately increased SL did not interfere with the circadian rhythmicity of HR, BP or LA. A prominent decrease in amplitude and spectral power of circadian oscillations was observed if food was available during the lighttime. Combination of PDS with FR split cardiovascular and behavioural parameters. In conclusion, food availability during the light-time in combination with PDS decreased amplitude and spectral power of circadian oscillations of BP, HR and LA more than PDS only. Different response of cardiovascular and behavioural parameters to photic and non-photic stimuli can have consequences for shift workers.
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Molčan et al. (2015) studied this question. Phase delay shifts (PDS) of light combined with moderately increased salt intake or time restriction of food during the light-time vs. PDS alone was evaluated on Circadian oscillations of heart rate, blood pressure, and locomotor activity. Food availability during the light-time in combination with phase delay shifts decreased the amplitude and spectral power of circadian oscillations of blood pressure, heart rate, and locomotor activity more than phase delay shifts alone.
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