Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH2-terminal kinases
Why the study?
Does gene transfer of SEK-1(KR) prevent pressure overload-induced cardiac hypertrophy in adult rats?
Population
Adult rat heart model with pressure overload-induced cardiac hypertrophy
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Overview
May nominate SAPKs as hypertrophy targets; leaves open translation from rat models to human HF.
Structured PICO
Does gene transfer of SEK-1(KR) prevent pressure overload-induced cardiac hypertrophy in adult rats?
P
Population
Adult rat heart model with pressure overload-induced cardiac hypertrophy
I
Intervention
Adenovirus-mediated gene transfer of SEK-1(KR) (a dominant inhibitory mutant of the immediate upstream activator of the stress-activated protein kinases)
O
Outcome
Cardiac hypertrophy (assessed by echocardiography, left ventricular wall thickness, ratio of LV weight to body weight, cardiomyocyte diameter, and atrial natriuretic factor expression)surrogate
Inhibition of stress-activated protein kinases via SEK-1(KR) gene transfer prevents pressure overload-induced cardiac hypertrophy in vivo, identifying SAPKs as potential therapeutic targets for heart failure.
Cite This Study
Choukroun et al. (1999) studied this question.