Key result
Double valve replacement with reconstruction of the intervalvular fibrous body for infective endocarditis resulted in a 30-day mortality of 32% and a 5-year survival of 24.6%.
Cohort (n=25)
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Double valve replacement with reconstruction of the intervalvular fibrous body for infective endocarditis carries high perioperative mortality (32%) and morbidity, but remains a necessary salvage option for otherwise fatal disease.
OBJECTIVES: Destruction of the intervalvular fibrous body, though uncommon, occurs due to paravalvular abscess formation following active infective endocarditis. This warrants a highly complex operation involving radical surgical debridement of the intervalvular fibrous body, followed by double valve (aortic and mitral) replacement with patch reconstruction of the anterior mitral annulus, the left ventricular outflow tract and the left atrial roof. The objective of this study was to review the early and mid-term outcomes in patients undergoing this operation. METHODS: A total of 25 patients underwent double valve replacement with reconstruction of the intervalvular fibrous body for extensive infective endocarditis between January 1999 and March 2012. The mean age was 64.3 ± 10.5 years. Most of the patients (60%) were in New York Heart Association Class III-IV, 12% and in cardiogenic shock. Associated comorbidities like acute renal insufficiency and cerebrovascular accidents were observed in 40 and 20% of patients, respectively. Twenty patients had previous heart valve surgeries. The logistic EuroSCORE predicted risk of mortality was 55.1 ± 22.9%. RESULTS: Overall, 30-day mortality was 32%. Postoperative complications like low cardiac output, stroke and acute renal failure developed in 16, 28 and 56%, respectively. Thirty-two percent of patients required re-exploration for bleeding. Nine patients were alive at a mean follow-up of 406 days (0-8 years). The 2- and 5-year survivals were 37.0 ± 11.1 and 24.6 ± 12.5%, respectively. CONCLUSIONS: Double valve replacement with reconstruction of the intervalvular fibrous body for infective endocarditis is a complex, technically challenging operation associated with high perioperative morbidity and mortality. Nevertheless, being the only option available for such complex disease, it should be performed in these patients who, otherwise, face 100% mortality.
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Davierwala et al. (2013) conducted a cohort in active infective endocarditis (n=25). Double valve replacement and reconstruction of the intervalvular fibrous body was evaluated on 30-day mortality. Double valve replacement with reconstruction of the intervalvular fibrous body for infective endocarditis resulted in a 30-day mortality of 32% and a 5-year survival of 24.6%.
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