Key result
Children with cystic fibrosis had significantly higher arterial stiffness, measured by augmentation index (33.22% vs 24.93%; P<0.05), compared to healthy controls.
Why the study?
With increasing life expectancy, cardiovascular complications of cystic fibrosis have emerged, but arterial stiffness had not been compared between children with cystic fibrosis and healthy controls.
Does cystic fibrosis increase arterial stiffness in pediatric patients compared to healthy controls?
Case-Control (n=74)
Does cystic fibrosis increase arterial stiffness in pediatric patients compared to healthy controls?
Absolute Event Rate: 33.22% vs 24.93%
p-value: p=< .05
Children with cystic fibrosis demonstrate increased arterial stiffness (measured by augmentation index) compared to healthy controls, suggesting early cardiovascular risk.
Increased arterial stiffness in children with cystic fibrosis may indicate early vascular involvement; leaves open its prognostic value and clinical utility.
With the increase in life expectancy, cardiovascular complications of cystic fibrosis (CF) have come to the forefront. Increased arterial stiffness is a marker of increased cardiovascular risk. The aim of this study was to compare both pulse wave velocity (PWV) and augmentation index (Aix) measurements in children with CF and to compare them with healthy controls. We hypothesized that children with CF had increased arterial stiffness, although traditional risk factors for CVD were not observed. Forty-four patients and age and sex-matched 30 healthy controls were included in the study. Hemodynamic measurements were compared in both groups, together with traditional risk factors. Peripheral blood pressure parameters of CF and control groups were similar (P > .05). Bodyweight and BMI were significantly lower in the CF group (P < .001). Serum cholesterol, HDL, and LDL levels were significantly lower in the CF group, whereas fasting blood glucose and triglyceride levels were significantly higher than the control group (P < .05). Mean ± SD Aix was significantly higher in the CF group (33.22 ± 13.87%) compared with the control group (24.93 ± 10.58%), respectively (P < .05), while PWV was similar. No significant correlation between PWV and Aix and fasting blood glucose and lipid profile in both groups (P > .05). Children with CF have been shown to have increased arterial stiffness compared to healthy children. Although there are not many traditional risk factors, increased arterial stiffness have been demonstrated in children with CF. The effects of this process starting from childhood on the development of CVD in adulthood are not known. Therefore, further studies are needed.
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Öztürk et al. (2020) conducted a case-control in Cystic fibrosis (n=74). Cystic fibrosis vs. Healthy controls was evaluated on Augmentation index (Aix) (p=< .05). Children with cystic fibrosis had significantly higher arterial stiffness, measured by augmentation index (33.22% vs 24.93%; P<0.05), compared to healthy controls.
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