Why the study?
Do angiotensin II and noradrenaline infusions alter central pulse pressure and arterial stiffness differently than peripheral pulse pressure in healthy men?
Population
8 healthy male subjects, mean age 30 years
Comparison
Intravenous infusion of angiotensin II and… vs Matching placebo
Design
RCT, random order
Authors
Loading...
Peripheral pulse pressure is an unreliable surrogate for central changes during vasoactive infusions; extends RCT evidence of divergent central-peripheral responses.
Do angiotensin II and noradrenaline infusions alter central pulse pressure and arterial stiffness differently than peripheral pulse pressure in healthy men?
Peripheral pulse pressure does not reliably predict changes in central pulse pressure or arterial stiffness in response to vasoactive drugs.
Wilkinson et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: