Why the study?
Does CVT-510 slow AV nodal conduction without the negative inotropic and hypotensive effects of diltiazem in guinea-pig models?
Population
Guinea-pig models (atrial-paced isolated heart and atrial-paced anaesthetized guinea-pigs)
Comparison
CVT-510 (N-(3-tetrahydrofuranyl)-6-aminopurine… vs Diltiazem (calcium channel blocker)
Design
Preclinical
Authors
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May warrant investigation as a hemodynamically neutral AV nodal agent; leaves open translation beyond guinea-pig models.
Does CVT-510 slow AV nodal conduction without the negative inotropic and hypotensive effects of diltiazem in guinea-pig models?
In guinea-pig models, the A1 adenosine receptor agonist CVT-510 effectively slows AV nodal conduction without the negative inotropic and hypotensive effects associated with diltiazem.
Snowdy et al. (1999) studied this question.
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