November 3, 2012Current Opinion in Cardiology
Unexplained sudden death, focussing on genetics and family phenotyping
Key result
Molecular autopsy and familial cardiological evaluation are supported by recent genetic studies for identifying at-risk family members of sudden arrhythmic death syndrome cases.
Population
Young and apparently healthy individuals affected by unexplained sudden death and sudden arrhythmic death…
Design
Review
Authors
Discussion
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Member takes
Implication
Supports molecular autopsy and familial evaluation in SADS families; leaves open need for prospective validation before routine adoption.
Structured PICO
P
Population
Young and apparently healthy individuals affected by unexplained sudden death and sudden arrhythmic death syndrome (SADS), and their surviving family members
E
Exposure
Familial cardiological evaluation and molecular autopsy
O
Outcome
Identification of at-risk family members and underlying genetic causes
This review highlights the importance of familial cardiological evaluation and molecular autopsy in identifying genetic risks in families affected by sudden arrhythmic death syndrome.
Cite This Study
Raju et al. (2012) conducted a review in Unexplained sudden death and sudden arrhythmic death syndrome (SADS). Molecular autopsy and familial evaluation was evaluated. Molecular autopsy and familial cardiological evaluation are supported by recent genetic studies for identifying at-risk family members of sudden arrhythmic death syndrome cases.