Key result
Patients with mild asthma exhibited a 2.41-fold increased expression of the fast myosin heavy chain isoform (SM-B) in airway smooth muscle compared to healthy controls.
Cross-Sectional (n=27)
No
Effect estimate: 2.41-fold increase
Absolute Event Rate: 2.41% vs 1%
p-value: p=<0.006
May support isoform-targeted interventions in asthma; hypothesis-generating and should not alter practice pending validation.
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Léguillette et al. (2008) conducted a cross-sectional in Asthma (n=27). Asthma vs. Healthy controls was evaluated on mRNA expression of SM-B SMMHC isoform (2.41-fold increase, p=<0.006). Patients with mild asthma exhibited a 2.41-fold increased expression of the fast myosin heavy chain isoform (SM-B) in airway smooth muscle compared to healthy controls.
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