Key result
Bronchial smooth muscle cells from asthmatic subjects showed significantly increased maximum shortening capacity (39.05% vs 28.6%) and velocity (7.2% vs 5.23%/s) compared with normal cells.
Authors
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May explain airway hyperresponsiveness in asthma; leaves open therapeutic targeting of smooth muscle contractility.
Observational (n=18)
Absolute Event Rate: 39.05% vs 28.6%
Ma et al. (2002) conducted an observational in Asthma (n=18). Asthma vs. Normal subjects was evaluated on Maximum shortening capacity (Delta L max) of resting cell length. Bronchial smooth muscle cells from asthmatic subjects showed significantly increased maximum shortening capacity (39.05% vs 28.6%) and velocity (7.2% vs 5.23%/s) compared with normal cells.
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