What question did this study set out to answer?

To evaluate whether Astragalus membranaceus attenuates intestinal mucosa injury caused by ischemia-reperfusion and to investigate its underlying antioxidative mechanisms in rats.

January 1, 2011The American Journal of Chinese Medicine

Treatment with Astragalus membranaceus Produces Antioxidative Effects and Attenuates Intestinal Mucosa Injury Induced by Intestinal Ischemia-Reperfusion in Rats

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Authors

RCRongfa ChenSugarcane Research Center (Brazil)HSHua ShaoShandong First Medical University SLShiqing LinSun Yat-sen University

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Implication

Animal study demonstrates that Astragalus membranaceus reduces intestinal mucosa damage in a rat hemorrhagic shock model, suggesting therapeutic protection via antioxidative pathways.

Key Points

To evaluate whether Astragalus membranaceus attenuates intestinal mucosa injury caused by ischemia-reperfusion and to investigate its underlying antioxidative mechanisms in rats.
Established an intestinal ischemia-reperfusion injury model induced by hemorrhagic shock in rats.
Administered intravenous Astragalus membranaceus at a dose of 20 g crude drug/kg.
Assessed intestinal mucosal antioxidant activity, Chiu's score for mucosal injury, and the apoptosis index.
Intravenous Astragalus membranaceus produced significant antioxidative effects in the intestinal mucosa following ischemia-reperfusion (p < 0.05).
Astragalus membranaceus treatment significantly attenuated intestinal mucosal injury, as reflected by reduced Chiu's scores and lower apoptosis indices (p < 0.05).

Cite This Study

Chen et al. (2011) studied this question.

synapsesocial.com/papers/6a70657fe5469ee92be12343 https://doi.org/10.1142/s0192415x11009275

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Implication

Animal study demonstrates that Astragalus membranaceus reduces intestinal mucosa damage in a rat hemorrhagic shock model, suggesting therapeutic protection via antioxidative pathways.

Treatment with Astragalus membranaceus Produces Antioxidative Effects and Attenuates Intestinal Mucosa Injury Induced by Intestinal Ischemia-Reperfusion in Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Treatment with Astragalus membranaceus Produces Antioxidative Effects and Attenuates Intestinal Mucosa Injury Induced by Intestinal Ischemia-Reperfusion in Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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