Why the study?
Does acute creatine kinase inhibition alter contractile performance and metabolism in isolated single myocytes?
Does acute creatine kinase inhibition alter contractile performance and metabolism in isolated single myocytes?
Initial phosphocreatine hydrolysis in single skeletal muscle fibers is crucial for maintaining sarcoplasmic reticulum Ca2+ release and peak tension during repetitive contractions.
No takes yet. Share an insight, caveat, or question.
CK inhibition impairs tension maintenance in isolated myocytes; extends mechanistic insight on phosphocreatine but leaves open in vivo relevance.
Kindig et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: