Key result
Both regional cerebral oxygen saturation (r = -0.5198) and central venous oxygen saturation (r = -0.4821) measured after sternal closure strongly correlated with time to extubation in OPCABG patients.
Why the study?
It was unknown whether central venous oxygen saturation (ScvO2) or regional cerebral oxygen saturation (rSO2) is a better predictor of prognosis in patients undergoing off-pump coronary artery bypass grafting (OPCABG).
Do regional cerebral oxygen saturation (rSO2) and central venous oxygen saturation (ScvO2) predict time to extubation in patients undergoing off-pump coronary artery bypass grafting?
Observational (n=56)
No
Do regional cerebral oxygen saturation (rSO2) and central venous oxygen saturation (ScvO2) predict time to extubation in patients undergoing off-pump coronary artery bypass grafting?
Effect estimate: correlation coefficient r = -0.5198 (95% CI -0.6886 to -0.2976)
p-value: p=<0.0001
Both ScvO2 and rSO2 measured after sternal closure and upon ICU admission strongly correlate with time to extubation in patients undergoing off-pump CABG, suggesting their utility as prognostic markers.
Post-closure oxygen saturations may inform extubation timing in OPCABG; leaves open whether monitoring improves outcomes.
Objectives: Aim of the study was to compare central venous oxygen saturation (ScvO2) and regional cerebral oxygen saturation (rSO2) to see which of the two is better predictor of prognosis of patients undergoing off–pump coronary artery bypass grafting (OPCABG). Heart rate (HR), invasive blood pressures, and partial pressure of oxygen (pO2) have also been recorded to see if they are independent predictors of prognosis in OPCABG patients. Materials and Methods: A total of 56 patients undergoing OPCABG were included in the study. Baseline values and intraoperative values of ScvO2, rSO2, HR, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), pO2 at different time periods were recorded. Post-operatively the patients were shifted to Intensive care unit (ICU) on elective ventilation, and time to extubation since shifting to ICU were noted. Results:The ScvO2 values after sternal closure (correlation coefficient r= -0.4821, P=0.0002), and on shifting to ICU (correlation coefficient r= -0.4575, P=0.0004) showed strong correlation with time to extubation. Similarly the rSO2 values after sternal closure (correlation coefficient r=-0.5198, P<0.0001) and on shifting to ICU (correlation coefficient r = -o.5498, P<0.0001) showed strong correlation with time to extubation. HR SBP, DBP, MAP, pO2 individually didn’t show any correlation with time to extubation (P>0.05). Conclusion:ScvO2 and rSO2 both have strong correlation with time to extubation and are capable of predicting prognosis in OPCABG patients.
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Chaitali et al. (2022) conducted an observational in Patients undergoing off-pump coronary artery bypass grafting (OPCABG) (n=56). Regional Cerebral Oxygen Saturation (rSO2) and Central Venous Oxygen Saturation (ScvO2) monitoring was evaluated on Time to extubation (correlation with rSO2 after sternal closure) (correlation coefficient r = -0.5198, 95% CI -0.6886 to -0.2976, p=<0.0001). Both regional cerebral oxygen saturation (r = -0.5198) and central venous oxygen saturation (r = -0.4821) measured after sternal closure strongly correlated with time to extubation in OPCABG patients.
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