Key result
Central venous oxygen saturation <60% upon ICU admission after CABG was associated with a higher 30-day mortality risk compared to higher saturation levels (RR 4.2; 95% CI 2.4-7.2; p=0.001).
Why the study?
Does central venous oxygen saturation (ScvO2) < 60% upon ICU admission predict 30-day mortality in patients undergoing isolated CABG?
Cohort (n=515)
No
Does central venous oxygen saturation (ScvO2) < 60% upon ICU admission predict 30-day mortality in patients undergoing isolated CABG?
Relative Risk: 4.2 (95% CI 2.4–7.2)
p-value: p=0.001
In patients undergoing isolated CABG, a central venous oxygen saturation (ScvO2) < 60% upon ICU admission is strongly associated with a more than four-fold increased risk of 30-day mortality.
ScvO2 <60% was associated with higher CABG mortality; supports risk stratification but leaves open whether targeting improves outcomes.
Purpose: Central venous oxygen saturation (ScvO 2 ) has been reported as a prognostic marker of in-hospital mortality when it is below 60% in certain situations. Nevertheless, it has not been widely reported in patients undergoing coronary artery bypass graft (CABG). The study determined the association between ScvO 2 and in-hospital mortality in patients undergoing CABG in a high-complexity health institution in Santiago de Cali, Colombia. Patients and Methods: A retrospective cohort study was conducted with patients undergoing isolated CABG. The subject sample included 515 subjects aged 18 years or older. Exposure was defined as ScvO 2 < 60% upon admission to the intensive care unit (ICU) following surgery. The major outcome was mortality rates after 30 days. Furthermore, exposure variables were measured at preoperative, intra-operative, and postoperative time points. Results: A total of 103 exposed and 412 unexposed subjects were included. The final model revealed a higher mortality risk in individuals with ScvO 2 < 60% upon ICU admission compared with those with higher saturation levels (relative risk 4.2, 95% confidence interval: 2.4– 7.2; p = 0.001). Values were adjusted using variables such as age (> 75 years), low socioeconomic stratum, chronic kidney failure before surgery, unstable angina before surgery, ischemia time (> 60 min), and intra-operative inotrope use. The primary cause of death was cardiogenic shock (54.7%), followed by sepsis (25.0%) and postoperative bleeding (17.2%). Conclusion: The study identified an association between ScvO 2 < 60% and in-hospital mortality in patients undergoing CABG.
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Scarpetta et al. (2023) conducted a cohort in Coronary Artery Bypass Grafting (CABG) (n=515). Central venous oxygen saturation (ScvO2) < 60% upon ICU admission vs. ScvO2 ≥ 60% (higher saturation levels) was evaluated on Mortality rates after 30 days (RR 4.2, 95% CI 2.4-7.2, p=0.001). Central venous oxygen saturation <60% upon ICU admission after CABG was associated with a higher 30-day mortality risk compared to higher saturation levels (RR 4.2; 95% CI 2.4-7.2; p=0.001).
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