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Catch Fe if you can. Many siderophores are peptides biosynthesised by the well-studied nonribosomal peptide synthetase (NRPS) multienzyme family. However, recent research has demonstrated that several siderophores, for example desferrioxamine E, are assembled via an NRPS-independent siderophore (NIS) pathway. In this minireview, research progress to date on the NIS pathway is summarised, and the distribution and mechanistic rationalisations of the pathway are analysed.
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Gregory L. Challis (2005) studied this question.
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