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September 1, 1993Journal of Biological ChemistryOpen Access

Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors.

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BDBoris DrazninUniversity of Colorado Anschutz Medical CampusLCLing‐Chu ChangChina Medical UniversityJLJ. Wayne LeitnerCedars-Sinai Medical Center

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Draznin et al. (1993) studied this question.

synapsesocial.com/papers/6a7069d06ceb2bbd16dfe129https://doi.org/10.1016/s0021-9258(20)80685-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ras Activation by Insulin and Epidermal Growth Factor through Enhanced Exchange of Guanine Nucleotides on p21ras1993 · 173 citations
  2. 2Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects.1988 · 143 citations
  3. 3CDC25 : a Component of the RAS -Adenylate Cyclase Pathway in Saccharomyces cerevisiae1987 · 236 citations
  4. 4Interaction between the p21ras GTPase activating protein and the insulin receptor.1992 · 46 citations
  5. 5Activation of Ras by insulin in 3T3 L1 cells does not involve GTPase-activating protein phosphorylation.1992 · 73 citations