Key result
Clinical and pharmacogenetic factors, specifically OPRM1 rs1799971 (p=0.006) and ABCG2 rs2231142 (p=0.041), were significantly associated with recovery time from general anesthesia.
Why the study?
Are clinical and pharmacogenetic factors associated with recovery time from general anesthesia?
Observational
Are clinical and pharmacogenetic factors associated with recovery time from general anesthesia?
p-value: p=0.006 and 0.041
Clinical and pharmacogenetic factors, including OPRM1 and ABCG2 variants, are significantly associated with recovery time from general anesthesia and can inform predictive algorithms.
Should not guide anesthesia decisions; hypothesis-generating for OPRM1/ABCG2 variants in recovery.
AIM: Delayed recovery from general anesthesia is a well-known complication that requires predictive tools and approaches. This study aimed to determine significant factors associated with postanesthesia recovery and to develop an algorithm for estimating recovery time from general anesthesia. MATERIALS & METHODS: The genotypes of patients were determined by SNaPshot or ARMS-qPCR. The algorithm was developed via machine-learning and tested by the worm plot. RESULTS: Results showed that OPRM1 rs1799971 (p = 0.006) and ABCG2 rs2231142 (p = 0.041) were significantly associated with recovery time. Ten factors after random forest and stepwise selection were associated with recovery time. Ten factors after random forest and stepwise selection were associated with recovery time. Meanwhile, seven factors were associated with delayed recovery. CONCLUSION: This study demonstrated that both clinical and pharmacogenetic data are significantly associated with recovery from general anesthesia and provide the basis for pre-emptive prediction tools.
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Xie et al. (2018) conducted an observational in General anesthesia recovery. Clinical and pharmacogenetic factors (OPRM1 rs1799971 and ABCG2 rs2231142) was evaluated on Recovery time from general anesthesia (p=0.006 and 0.041). Clinical and pharmacogenetic factors, specifically OPRM1 rs1799971 (p=0.006) and ABCG2 rs2231142 (p=0.041), were significantly associated with recovery time from general anesthesia.
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