Key result
Patients with a fatal outcome of traumatic brain injury had significantly higher initial serum cortisol levels (median 2097.3 nmol/L) compared to those with a favorable outcome (median 533.2 nmol/L).
Why the study?
The study was conducted to assess serum cortisol dynamics as a criterion for treatment effectiveness in patients with traumatic brain injury.
Do serum cortisol levels correlate with fatal outcomes in patients undergoing surgery for traumatic brain injury?
Cohort (n=42)
Do serum cortisol levels correlate with fatal outcomes in patients undergoing surgery for traumatic brain injury?
Absolute Event Rate: 2097.3% vs 533.2%
p-value: p=0.0004
Persistently high serum cortisol levels during the perioperative period are associated with fatal outcomes in patients with traumatic brain injury.
Higher initial cortisol may aid early prognosis in TBI; leaves open validation as biomarker and any therapeutic role.
Objective. Assessment of the dynamics of cortisol in the serum as a criterion for the effectiveness of treatment of patients with traumatic brain injury (TBI).Material and methods. Of the 42 patients operated because of TBI, two groups were formed. Group 1 – 36 patients with a favorable outcome, group 2 – 6 patients with an unfavorable outcome. Comparison of cortisol between the groups was made at 4 stages of the study.Results. The value of cortisol in groups 1 and 2 the initial one was 533.2 (378.1; 860.0), 2097.3 (866.9; 2568.5) nmol /l, respectively; when removing the hematoma – 432.5 (258.8; 897.8), 1592.8 (1095.9; 3586.6) nmol /l; the end of the operation – 433.0 (218.0; 1021.5), 1183.2 (816.7; 2071.38) nmol /l; after surgery – 493.5 (351.6; 880.9), 1449.8 (1334.5; 2141.2) nmol /l. At all stages, p <0.05.Conclusions. In patients with fatal TBI, high serum cortisol values were detected at all stages of the study.
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Markevich et al. (2019) conducted a cohort in Traumatic brain injury (n=42). Fatal outcome of traumatic brain injury vs. Favorable outcome was evaluated on Initial serum cortisol level (nmol/L) (p=0.0004). Patients with a fatal outcome of traumatic brain injury had significantly higher initial serum cortisol levels (median 2097.3 nmol/L) compared to those with a favorable outcome (median 533.2 nmol/L).
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