Primary Progressive Aphasia: Variants and Main Language Domains

Language is one of the higher brain functions and the primary method of communication, so it plays a key role in human social functioning. Primary progressive aphasia, as a slowly progressive neurodegenerative disease with a clinical predominance of different speech and language disorders, is a promising model for a more detailed study of topographic distribution of language disorders. This review presents data on different clinical variants of primary progressive aphasia and the corresponding clinical and neuroanatomical correlates that have significantly expanded the modern understanding of the neural network language organization.