What question did this study set out to answer?

To evaluate the association between post-operative delirium and long-term cognitive decline or dementia in elderly individuals.

January 1, 2006Dementia and Geriatric Cognitive Disorders

Post-Operative Delirium Is Associated with Poor Cognitive Outcome and Dementia

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Why the study?

Does post-operative delirium increase the risk of cognitive decline and dementia in elderly subjects undergoing hip or knee replacement?

Population

90 elderly subjects, non-demented at baseline

Comparison

Occurrence of post-operative delirium (n=31) vs No post-operative delirium (controls)

Design

Cohort

Authors

PWPriscilla WackerUniversidade de São Paulo PNPaula Villela NunesUniversity of British Columbia HCHenrique CabritaHospital Israelita Albert Einstein

Discussion

Member takes

Implication

Post-operative delirium may flag elderly arthroplasty patients for closer cognitive surveillance; leaves open whether it is causal or a marker of shared vulnerability.

Key Points

To evaluate the association between post-operative delirium and long-term cognitive decline or dementia in elderly individuals.
Reviewed hospital files of 572 patients who underwent hip or knee replacement between 1998 and 2004.
Screened a sample of 90 elderly subjects (31 with post-operative delirium, 59 controls) who were non-demented at baseline for cognitive decline and dementia using the IQCODE.
Post-operative delirium was strongly associated with incident dementia, with a relative risk of 10.5 (95% CI: 3.3–33.2).
Patients with post-operative delirium had a significantly higher mean IQCODE score than controls (3.75 vs. 3.1; p < 0.001), with the greatest deficits observed in memory, orientation, and abstract thinking.

Structured PICO

Does post-operative delirium increase the risk of cognitive decline and dementia in elderly subjects undergoing hip or knee replacement?

Population

90 elderly subjects (sampled from 572 patients who underwent hip or knee replacement between 1998 and 2004), non-demented at baseline

Intervention

Occurrence of post-operative delirium (n=31)

Comparator

No post-operative delirium (controls)

Outcome

Cognitive decline and diagnosis of dementia (assessed via IQcode screening)hard clinical

Post-operative delirium in cognitively unimpaired elderly subjects is strongly associated with a worse cognitive outcome and an increased risk of dementia.

Cite This Study

Wacker et al. (2006) studied this question.

synapsesocial.com/papers/6a706b7bfebe604dd709356b https://doi.org/10.1159/000091022

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Implication

Post-operative delirium may flag elderly arthroplasty patients for closer cognitive surveillance; leaves open whether it is causal or a marker of shared vulnerability.

Post-Operative Delirium Is Associated with Poor Cognitive Outcome and Dementia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Post-Operative Delirium Is Associated with Poor Cognitive Outcome and Dementia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider