Understanding the amino acid sequences of sarcomeric myosin isoforms provides insights into the molecular basis of their energy conversion versatility.
Should not yet change sarcomeric cardiomyopathy management; leaves open isoform-specific therapeutic targeting.
Sarcomeric or striated muscle myosins are the molecular motors whose fine tuning is best known. Sarcomeric myosin isoforms convert chemical into mechanical energy at very different rates without losing efficiency. Availability of the amino acid sequences offers for the first time the chance to understand the molecular basis of the versatility of these molecular motors.
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Reggiani et al. (2000) studied this question.
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