Key result
The in vitro motility assay enables the probing of molecular events that couple ATP hydrolysis to mechanical work at the level of a single myosin molecular motor.
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Design
Review
Advances in vitro myosin analysis without immediate clinical impact; leaves open cardiac disease model applications.
Muscular contraction is powered by myosin, a molecular motor, that derives its energy from hydrolysis of ATP as it interacts with actin. With the development of the in vitro motility assay, molecular events that couple ATP hydrolysis to mechanical work can be probed at the level of a single myosin molecular motor.
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DM Warshaw (1996) studied this question. The in vitro motility assay enables the probing of molecular events that couple ATP hydrolysis to mechanical work at the level of a single myosin molecular motor.
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