What question did this study set out to answer?

To evaluate the biological role of inhibitor of apoptosis (IAP) proteins in tumor development and assess strategies for targeting them in cancer therapy.

October 15, 2007Clinical Cancer ResearchOpen Access

The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer

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Authors

DVDomagoj VucicGene Therapy Laboratory WFWayne J. FairbrotherGene Therapy Laboratory

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Implication

Review highlights the role of inhibitor of apoptosis proteins in tumor survival and treatment resistance, indicating their potential as cancer drug targets.

Key Points

To evaluate the biological role of inhibitor of apoptosis (IAP) proteins in tumor development and assess strategies for targeting them in cancer therapy.
Narrative synthesis of the molecular mechanisms of inhibitor of apoptosis (IAP) proteins in cellular homeostasis and programmed cell death.
Review of preclinical and therapeutic approaches designed to target IAP proteins across human malignancies.
Inhibitor of apoptosis (IAP) proteins are overexpressed across the majority of human cancers, enabling malignant cells to evade immune surveillance and cytotoxic therapies.
IAP family proteins prevent cell death by directly interfering with apoptotic inducers and effectors and actively driving oncogenic signaling cascades.

Cite This Study

Vucic et al. (2007) studied this question.

synapsesocial.com/papers/6a706c8f660549caf2c5017e https://doi.org/10.1158/1078-0432.ccr-07-0729

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Implication

Review highlights the role of inhibitor of apoptosis proteins in tumor survival and treatment resistance, indicating their potential as cancer drug targets.

The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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