Key result
Obesity and visceral adipose tissue contribute significantly to the development and progression of liver diseases, including NAFLD, NASH, and hepatocellular carcinoma, via lipotoxicity and inflammation.
Population
Individuals with obesity and associated liver disorders such as nonalcoholic fatty liver disease…
Design
Review
Authors
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May guide NAFLD risk stratification; leaves open whether visceral fat reduction alters progression or HCC incidence.
Obesity and visceral adipose tissue play a critical role in the pathogenesis and progression of liver diseases, including NAFLD, NASH, and hepatocellular carcinoma, primarily through lipotoxicity and inflammatory pathways.
Wree et al. (2010) conducted a review in Obesity and liver diseases (NAFLD, NASH, hepatocellular carcinoma). Obesity and visceral adipose tissue was evaluated. Obesity and visceral adipose tissue contribute significantly to the development and progression of liver diseases, including NAFLD, NASH, and hepatocellular carcinoma, via lipotoxicity and inflammation.
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