Key result
A three-state power stroke model demonstrates that the dependence of power and reversal stroke rate constants on elastic element strains plays a key role in molecular motor spontaneous oscillations.
This computational study identifies the essential conditions for spontaneous oscillations in a three-state power-stroke model of molecular motors, highlighting the role of strain-dependent rate constants.
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Strain-dependent rates may drive motor oscillations in models; leaves open experimental validation in biological systems.
Washio et al. (2017) studied this question. Three-state power-stroke model vs. Two-state model was evaluated on Spontaneous oscillations of molecular motors. A three-state power stroke model demonstrates that the dependence of power and reversal stroke rate constants on elastic element strains plays a key role in molecular motor spontaneous oscillations.
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