Why the study?
Does wide excision or adjuvant radiotherapy improve survival or reduce recurrence in patients with angiosarcoma?
Does wide excision or adjuvant radiotherapy improve survival or reduce recurrence in patients with angiosarcoma?
In patients with angiosarcoma, wide excision improves survival and adjuvant radiotherapy reduces recurrence.
May support wide excision and radiotherapy in angiosarcoma; hypothesis-generating from Level 3 data and needs prospective validation.
Twenty patients with angiosarcoma (six male and fourteen female) treated at National Cancer Center Hospital between April 1982 and December 2000 were reviewed. The median age was 66 years (range 32 to 87 years) . The median followup was 13 months (range 2 to 112 months) . Ten patients had developed regional lymph node metastases. Seventeen patients had developed distant metastases. The 5-year survival rate was 20%. Fourteen patients underwent surgery, seventeen underwent radiotherapy, nine underwent chemotherapy, thirteen underwent IL-2 therapy and two underwent IFN therapy. Compared with the patients who didn't undergo wide excision, the patients who underwent wide excision showed a statistically significant increase in survival rate (p=0.029). Compared with the patients who didn't undergo adjuvant radiotherapy, the patients who underwent adjuvant radiotherapy showed a statistically significant decrease in recurrence rate (p=0.018) . [Skin Cancer (Japan) 2001; 16: 361-366]
No takes yet. Share an insight, caveat, or question.
Machida et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: