Key result
Preoperatively elevated prothrombin time was not significantly associated with the occurrence of hemorrhagic complications requiring repeat surgery in patients undergoing elective neurosurgical procedures (p = 0.12).
Why the study?
Does routine preoperative prothrombin time screening predict hemorrhagic complications in patients undergoing elective neurosurgical procedures?
Population
4,310 patients admitted to general wards for routinely planned neurosurgical surgery between 2006 and 2010.
Design
Cohort
Follow-up
perioperative
Authors
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Preoperative PT elevation does not predict reoperation for bleeding; leaves open whether selective testing improves risk stratification in elective neurosurgery.
Observational (n=4,310)
No
Does routine preoperative prothrombin time screening predict hemorrhagic complications in patients undergoing elective neurosurgical procedures?
Absolute Event Rate: 2.6% vs 0.73%
p-value: p=0.12
Routine preoperative prothrombin time testing has limited value in elective neurosurgical patients with a normal history, as unexpected PT elevations are rare and not significantly associated with hemorrhagic complications.
Dützmann et al. (2012) conducted an observational in Elective neurosurgical procedures (n=4,310). Preoperatively elevated prothrombin time (INR > 1.28) vs. Normal preoperative prothrombin time was evaluated on Hemorrhagic complications requiring repeat surgery (p=0.12). Preoperatively elevated prothrombin time was not significantly associated with the occurrence of hemorrhagic complications requiring repeat surgery in patients undergoing elective neurosurgical procedures (p = 0.12).
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