June 14, 2005Respiratory ResearchOpen Access

Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury

View Full Paper

Ask AI

Bookmark

Why the study?

Does inhibition or knockout of iNOS reduce bleomycin-induced lung injury in mice?

Structured PICO

Does inhibition or knockout of iNOS reduce bleomycin-induced lung injury in mice?

Population

Mice subjected to intratracheal administration of bleomycin (wild-type and iNOS knockout models)

Intervention

iNOS knockout or treatment with GW274150 (selective iNOS inhibitor, 5 mg/kg i.p.)

Comparator

Wild-type mice treated with bleomycin (without inhibitor)

Outcome

Indicators of lung injury (body weight loss, mortality rate, MPO activity, edema formation, histological evidence of lung injury, lung collagen deposition, and lung TGF-beta1 expression)surrogate

Inhibition or genetic knockout of iNOS significantly attenuates bleomycin-induced lung injury and inflammation in mice.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports iNOS inhibition in preclinical lung injury; leaves open translation to human disease.

Cite This Study

Genovese et al. (2005) studied this question.

synapsesocial.com/papers/6a706ff8a2d7cf2e39c2a995 https://doi.org/10.1186/1465-9921-6-58

View Full Paper

Ask AI

Bookmark

Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury

Structured PICO

Discussion

Implication

Cite This Study

Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider