Population
Wild-type (WT) and bid(-/-) mice, and alveolar epithelial cells isolated from WT and bid(-/-) mice
Comparison
Intratracheal instillation of bleomycin and… vs WT mice vs. bid(-/-) mice
Design
Preclinical
Follow-up
5 days (for bronchoalveolar lavage fluid assessment)
Authors
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Bid inhibition may attenuate fibrosis; hypothesis-generating in mice, human validation required before any clinical consideration.
The proapoptotic Bcl-2 family member Bid is a critical regulator required for the development of pulmonary fibrosis downstream of TGF-beta1 activation.
Budinger et al. (2006) studied this question.
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