Key result
Hypertension was an independent predictor of significant proteinuria (AOR 2.433) in an outpatient screening population in Northern Ghana, where 10.7% of participants had significant proteinuria.
Why the study?
Chronic kidney disease incidence is increasing worldwide and characterized by late presentation in sub-Saharan Africa, with hypertension and proteinuria serving as independent risk factors for worsening kidney function.
What is the prevalence and what are the predictors of undiagnosed hypertension and proteinuria in an outpatient population in Northern Ghana?
Cross-Sectional (n=1,018)
Yes
What is the prevalence and what are the predictors of undiagnosed hypertension and proteinuria in an outpatient population in Northern Ghana?
Odds Ratio: 2.433 (95% CI 1.582–3.742)
p-value: p=<0.001
Uncontrolled hypertension and proteinuria are highly prevalent in the outpatient population of Northern Ghana, highlighting the need for community-based screening to detect and manage chronic kidney disease risk factors early.
Highlights hypertension/proteinuria burden in Northern Ghana; leaves open whether targeted screening improves CKD outcomes in similar settings.
Background: There is an upsurge in chronic kidney disease incidence worldwide. Late presentation characterises chronic kidney disease in sub-Saharan Africa. Hypertension and proteinuria are independent risk factors for worsening kidney function, irrespective of the cause of the kidney disease. We assessed the prevalence and predictors of hypertension and proteinuria in an outpatient population in Northern Ghana. Methods: We retrospectively reviewed screening data among adults ≥18 years of age in two of Ghana’s Northern regions. The data retrieved included socio-demographic information, blood pressure recordings, urine dipsticks and fingerpick blood glucose levels. The data were analysed for the prevalence of hypertension and proteinuria in the participants. Binary logistic regression analysis was employed to identify the predictors of significant proteinuria in these participants. A p-value <0.05 was considered statistically significant. Results: Total 1018 participants were included in the study, comprising 50.5% males. The prevalence of uncontrolled hypertension was 28.1%, using a blood pressure cut-off value of ≥ 140/90 mmHg. Significant proteinuria (≥ 1+ or 30 mg/dl) was present in 10.7% of the participants. Hypertension (AOR 2.433, 95% CI 1.582-3.742, p<0.001) and hyperglycaemia (AOR 2.226, 95% CI 1.159-4.275, p=0.016) were independent predictors of the presence of significant proteinuria. Conclusions: Uncontrolled hypertension and proteinuria were common in this outpatient population in Northern Ghana. The cost-effectiveness of community-based screening for chronic kidney disease and its risk factors in low-resource settings like Ghana, with the aim to treat to improve outcomes, needs to be explored.
No takes yet. Share an insight, caveat, or question.
Yakubu et al. (2024) conducted a cross-sectional in Undiagnosed hypertension and proteinuria (n=1,018). Hypertension vs. Normotension was evaluated on Significant proteinuria (≥ 1+ or 30 mg/dl) (AOR 2.433, 95% CI 1.582-3.742, p=<0.001). Hypertension was an independent predictor of significant proteinuria (AOR 2.433) in an outpatient screening population in Northern Ghana, where 10.7% of participants had significant proteinuria.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: