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This article reviews the historical development, chemical properties, metabolism, indications, contraindications, and adverse effects of amiodarone in infants and children.
This article reviews the use, indications, and complications of amiodarone for emergency arrhythmia care in infants and children.
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Highlights considerations for amiodarone in infants and children; leaves open definitive recommendations pending further evidence.
Amiodarone is a class 3 antiarrhythmic agent used for a broad range of arrhythmias including adenosine-resistant supraventricular tachycardia, junctional ectopic tachycardia, and ventricular tachycardia. Compared with adults, there are few data on its use in children with arrhythmias resistant to conventional therapy. National and international guidelines for cardiopulmonary resuscitation and emergency cardiovascular care recommend its use for a variety of arrhythmias based on case reports, cohort studies, and extrapolation from adult data. This article will review the historical development, chemical properties, metabolism, indications and contraindications, and adverse effects of amiodarone in infants and children. After completing this CME activity, the reader should be able to utilize amiodarone in the pediatric population for arrhythmias and identify complications associated with its use.
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Lane et al. (2010) conducted a review in Arrhythmias in infants and children. Amiodarone was evaluated. This article reviews the historical development, chemical properties, metabolism, indications, contraindications, and adverse effects of amiodarone in infants and children.
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